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NAC lev- els should not be higher than 1200 mg/kg [1315]

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Inhibition of glutamine synthetase can trigger the conversion of M2-like TAMs to the more inflammatory M1-like phenotype, thus impeding tumor metastasis (77, 78)

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Hypocalcemia occurs when there is an insufficient level of serum calcium due to conditions such as hypoparathyroidism, Vitamin D deficiency, or renal/hepatic disorders

3D) and total IGF-1 mRNA (Fig